How many risperdal to overdose

Decontamination: Not routinely indicated Enhanced Elimination Not clinical useful Antidote Benztropine for acute dystonic reactions. Over 3 yrs 0. Adults 1mg. May repeat in 15 minutes. Disposition Children who are symptomatic all need review Patients who are well with a normal baseline ECG can be medically cleared at 4 hours post ingestions Symptomatic patients need supportive care until toxicity resolves Patients should be warned that extrapyramidal movements may occur up to 3 days later.

References: Burns MJ. The pharmacology and toxicology of atypical antipsychotic agent s. Journal of Toxicology-Clinical Toxicology ; 39 1 : Cobaugh DJ et al. Atypical antipsychotic medication poisoning an evidence based consensus guideline for out-of-hospital management. Risperidone overdose causes extrapyramidal effects but not cardiac toxicity. A systematic review of cardiovascular effects after atypical antipsychotic medication overdose. American Journal of Emergency Medicine ; Tox Library.

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Major effects in these patients included lethargy 10 , coma 1 , seizure 1 , tachycardia 7 , bradycardia 1 , hypotension 4 , and a syndrome of muscle spasms, diaphoresis, and fever. One patient who coingested imipramine died of medical complications. In the remaining patients, symptoms resolved with 24 hours in the majority, with all patients asymptomatic at 72 hours postingestion.

These data show that risperidone toxicity manifests primarily as mild central nervous system effects and reversible neuromuscular and cardiovascular effects.

Median length of stay was 16 hours IQR, hours , and none was ventilated or admitted to the intensive care unit. On review of electrocardiograms in 41 of the 45 cases where risperidone was ingested alone, there were no acute dysrhythmias.

Conclusions: Risperidone taken alone in overdose causes minimal effects. Tachycardia and dystonic reactions were the main features of toxicity.